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      The Magnesium Project -Metabolomics

    Definition

Metabolomics is the study of metabolism and the various biochemical pathways,  components and regulatory systems associated with it.  Metabolomics also includes the processes involved in breakdown of compounds (catabolism) as well as the formation of new compounds (anabolism).

    Diseases of Metabolism

    Diseases of metabolism cover a lot of area.  Diseases are characterized by one or more defects in the genetic code or the translation thereof in going from reading of a segment of the DNA code to formation of mRNA and subsequent forms of RNA that direct protein synthesis.  Diseases are often the result of an accumulation of one or more mutations, copy number variations (CNV) or single nucleotide polymorphisms (SNP).  There are more than  1600 metabolic pathways each of which may be comprised of dozens of enzyme catalyzed reactions. Thus, there are many opportunities for mistakes to happen.  Mistakes in fact do happen but there are also systems in place to discard the "mistakes."  The mechanisms to detect and discard misformed proteins may also be defective and become a contributor to a particular disease.

    Diabetes Melitus (Type II)

    Diabetes is a disease related to the metabolism of sugar/carbohydrates ...

    Distinguished from Type I (Juvenile diabetes) which is an auto-immune disease in which the body immune system cells attack the pancreatic cells....[EDIT ]

    Several components of the system - glucagon, insulin

    Structures - pancreas - Islets of Langerhan and Eccrine cells ...[EDIT ]

     

    Genetic conditions that may be pre-disposing to any of the foregoing conditions are yet to be evaluated. For further treatment of genetics see the Genomics pages.

    References

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    This page is under development.

    Links to major topics only are live.

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